Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism

W De Nardo; PM Miotto; J Bayliss; S Nie; SN Keenan; MK Montgomery; MJ Watt

Journal article

Proteomic analysis reveals exercise training induced remodelling of hepatokine secretion and uncovers syndecan-4 as a regulator of hepatic lipid metabolism

W De Nardo, PM Miotto, J Bayliss, S Nie, SN Keenan, MK Montgomery, MJ Watt

Molecular Metabolism | Published : 2022

DOI: 10.1016/j.molmet.2022.101491

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Abstract

Objective: Non-alcoholic fatty liver disease (NAFLD) is linked to impaired lipid metabolism and systemic insulin resistance, which is partly mediated by altered secretion of liver proteins known as hepatokines. Regular physical activity can resolve NAFLD and improve its metabolic comorbidities, however, the effects of exercise training on hepatokine secretion and the metabolic impact of exercise-regulated hepatokines in NAFLD remain unresolved. Herein, we examined the effect of endurance exercise training on hepatocyte secreted proteins with the aim of identifying proteins that regulate metabolism and reduce NAFLD severity. Methods: C57BL/6 mice were fed a high-fat diet for six weeks to indu..

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University of Melbourne Researchers

Paula Miotto Author

Jacqueline Bayliss Author

Stacey Keenan Author

Magda Montgomery Author

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Grants

Awarded by Natural Sciences and Engineering Research Council of Canada

Funding Acknowledgements

WD is supported by The University of Melbourne Research Scholarship. PMM was supported by a Canadian Institutes of Health Research (CIHR) post-doctoral fellowship and a Natural Sciences and Engineering Research Council of Canada (NSERC) post-doctoral fellowship. MKM is supported by a Career Development Fellowship from the National Health and Medical Research Council of Australia (ID: APP1143224) . These studies were supported by the NHMRC (APP1162511, APP1156508) .